[The organization of palliative medical care on the regional level].

The article considers particular issues of current state of palliative care organization, including out-patient stage of its provision, as exemplified by the Saratov Oblast. At the actual stage of national health care system development, palliative care system faces wide range of tasks that require immediate solutions, including significant list of diseases that determine palliative status of patients and number of patients in need of corresponding care. According to various estimates, in Russia more than 1.

[Comparative analysis of expression of TGFbeta family factors and their receptors in mouse embryonic stem and embryonic teratocarcinoma cells].

Specific factors that determine the cell fate in early embryogenesis are modulated during interaction of signaling pathways to form a unique regulatory network inside the cell, which is essential for differentiation of various cell populations. We carried out a comparative study of expression of the genes of TGFbeta growth factors and their receptors at the initial stages of differentiation of the embryonic stem cells, during formation of spheroids of the embryonic teratocarcinoma cells, and during growth of neoplastic cells in vivo in immunodeficient mice. The patterns of expression of the genes Activin, Nodal, Lefty1, Lefty2, BMP, and TGF1 and their receptors ActRI, ActRII, BMPRI, TGFbeta1R1, and Tdgf proved to be identical.

[Expression of regulatory genes Oct-4, Pax-6, Prox-1, Ptx-2 at the initial stages of differentiation of embryonic stem cells in vitro].

The expression of regulatory genes of the POU, Pax, Prox, and Ptx gene families was studied at the initial stages of differentiation of murine embryonic stem cells of R1 line. mRNAs were isolated from undifferentiated embryonic stem cells and embryoid bodies formed at the early stages of in vitro differentiation and cDNA sequences were synthesized for comparative PCR analysis of the expression of studied genes. The levels of expression of the gene Oct-4 involved in maintenance of the pluripotent status of embryonic stem cells proved to be practically indistinguishable in undifferentiated cells and embryoid bodies, while the expression of Pax-6 markedly increased in the latter.

[Cerebrolysin and magnesium-B6 in the treatment of side effects of psychotropic drugs].

51 patients were observed. Schizophrenia was diagnosed in 31 patients and endogenous depression in 20 cases. All the patients had extrapyramidal and somato-vegetative side effects of neuroleptics and antidepressive drugs, and were resistant to conventional corrective therapy for at least a period of 3 weeks.