Lactobacillus gasseri prevents ibrutinib-associated atrial fibrillation through butyrate.

Ibrutinib, a widely used anti-cancer drug, is known to significantly increase the susceptibility to atrial fibrillation (AF). While it is recognized that drugs can reshape the gut microbiota, influencing both therapeutic effectiveness and adverse events, the role of gut microbiota in ibrutinib-induced AF remains largely unexplored. Utilizing 16S rRNA gene sequencing, fecal microbiota transplantation, metabonomics, electrophysiological examination, and molecular biology methodologies, we sought to validate the hypothesis that gut microbiota dysbiosis promotes ibrutinib-associated AF and to elucidate the underlying mechanisms.

Analysis of HIV transmission characteristics and intervention effects in Guangxi based on molecular networks.

Objective: This study evaluates changes in HIV transmission and the effectiveness of interventions after two rounds of the Guangxi AIDS Conquering Project (GACP) in Guangxi, China.

Methods: Samples and epidemiological data from newly diagnosed people living with HIV (PLWH) between 2014-2020 were analyzed. Molecular networks were constructed using nested PCR amplification and sequencing of the pol region, and multivariable logistic regression identified factors associated with clustering and high-degree nodes.

The progression rate and risk factor analysis of small gastric subepithelial tumors: a systematic review and meta-analysis.

Background And Aims: Small gastric subepithelial tumors (SETs) in the stomach can be managed through surveillance or resection. However, it is still controversial how often the lesion would progress if left untreated. This study aimed to evaluate the progression rate of small SETs and identify risk factors influencing tumor growth.

Soft Metalens for Broadband Ultrasonic Focusing through Aberration Layers.

Aberration layers (AL) often present significant energy transmission barriers in microwave engineering, electromagnetic waves, and medical ultrasound. However, achieving broadband ultrasonic focusing through aberration layers like the human skull using conventional materials such as metals and elastomers has proven challenging. In this study, we introduce an inverse phase encoding method employing tunable soft metalens to penetrate heterogeneous aberration layers.

College students' disciplinary expertise and their entrepreneurial intentions: an exploratory study based on foreign language majors with experience in innovation and entrepreneurship training programs.

Taking foreign language majors with experience in innovation and entrepreneurship training program (IETP) as samples, this study investigates the influence of disciplinary expertise on entrepreneurial intention. Based on the theory of planned behavior (TPB), a model was designed to examine the relationships among entrepreneurial intentions, perceived behavioral control, attitude toward entrepreneurship, subjective norms, IETP experience, foreign language self-efficacy and cultural intelligence. The data were collected through questionnaires and Partial least squares structural equation modeling (PLS-SEM) was adopted to test the hypotheses.