Publications by authors named "N Xenidis"
Dihydropyrimidine dehydrogenase (DPD), encoded by gene, is the rate-limiting enzyme responsible for fluoropyrimidine (FP) catabolism. gene variants seriously affect DPD activity and are well validated predictors of FP-associated toxicity. variants rs3918290, rs55886062, rs67376798, and rs75017182 are currently included in FP genetic-based dosing guidelines and are recommended for genotyping by the European Medicines Agency (EMA) before treatment initiation.
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- A European registry was established for patients with advanced EGFR exon 20-mutant non-small cell lung cancer (NSCLC) diagnosed between January 2019 and December 2021, specifically excluding those enrolled in clinical trials.* -
- The final analysis included data from 175 patients across nine countries, revealing a median age of 64 years, predominantly affecting women (56.3%) and mostly comprising adenocarcinoma cases (95.4%) with frequent bone (47.4%) and brain (32.0%) metastases.* -
- Treatment patterns varied significantly: chemotherapy and chemotherapy-immunotherapy combinations were used in 33.8% and 18.2% of cases respectively, with disease control rates of
Aim: Carcinogenesis of colorectal cancer is a process involving genetic mutations and epigenetic alterations in its multiple phases. The most considerable epigenetic alteration occurring in colorectal cancer (CRC) tumorigenesis is the methylation-mediated silencing of tumor suppressor genes. The present study aimed to detect the methylation status of and promoters in cell-free DNA circulating in plasma of metastatic CRC patients and to investigate potential prognostic correlation.
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- * This study aimed to assess the frequency and importance of mutations in high-grade serous ovarian cancer (HGSOC) using droplet digital PCR (ddPCR) on tumor samples and plasma cfDNA from patients.
- * Findings revealed mutations in 15% of tumor samples and 13.8% of plasma cfDNA, marking a significant discovery in ovarian cancer research, but further validation in larger patient cohorts is necessary.
Autotaxin (ATX), encoded by the ctonucleotide pyrophosphatase/phosphodiesterase 2 () gene, is a key enzyme in lysophosphatidic acid (LPA) synthesis. We have recently described methylation profiles in health and multiple malignancies and demonstrated correlation to its aberrant expression. Here we focus on breast cancer (BrCa), analyzing in silico publicly available BrCa methylome datasets, to identify differentially methylated CpGs (DMCs) and correlate them with expression.
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