Alzheimers Dement
December 2024
Background: Cognitive decline is often influenced by Alzheimer's disease (AD) pathology (e.g., beta-amyloid burden) and other pathology (e.
View Article and Find Full Text PDFIntroduction: Targeted proteomic assays may be useful for diagnosing and staging Alzheimer's disease and related dementias (ADRD). We evaluated the performance of a 120-marker central nervous system (CNS) NUcleic acid-Linked Immuno-Sandwich Assay (NULISA) panel in samples spanning the AD spectrum.
Methods: Cross-sectional plasma samples (n=252) were analyzed using Alamar's NULISAseq CNS panel.
Background: Presently, where inactivity is an overarching problem globally, participation in recreational sports activities has become an important outlet for promoting healthy lifestyles. However, there is a lack of instruments to evaluate the commitment of recreational and leisure sports users. This study aimed to adapt, develop and provide preliminary validation of the Recreational Sport Commitment Questionnaire (RESQ).
View Article and Find Full Text PDFKarenia brevis blooms occur nearly annually along the southwest coast of Florida, and effective mitigation of ecological, public health, and economic impacts requires reliable real-time forecasting. We present two boosted random forest models that predict the weekly maximum K. brevis abundance category across the Greater Charlotte Harbor estuaries over one-week and four-week forecast horizons.
View Article and Find Full Text PDFIntroduction: Patterns of signal from tau positron emission tomography (tau-PET) confined to the medial temporal lobe (MTL) or extended into the neocortex may be relevant for Alzheimer's disease (AD) research if they are linked to differential biomarker levels and cognitive decline.
Methods: Visual assessment of Tau-PET [F-18]florquinitau (FQT) exams from 728 initially non-demented older adults yielded four uptake groups: tau-negative (T-), MTL-only (T+), neocortex-only (T+), or both (T+). Mixed effects models assessed group differences in retrospective cognitive and plasma pTau217 trajectories.