Publications by authors named "N Woodford"
Frequencies and mechanisms of mutational resistance to ceftibuten/avibactam in Enterobacterales.
J Antimicrob Chemother
December 2024
Article Synopsis
- Background: Antibiotic resistance in urinary infections is a significant issue, especially for infections that spread beyond the bladder. New oral combinations of β-lactamase inhibitors, such as ceftibuten/avibactam, are being developed and show promise against resistant strains.
- Methods: The study involved experimenting with various Enterobacterales strains to identify mutants that could resist treatment. Researchers evaluated the minimum inhibitory concentrations (MICs) and performed whole genome sequencing on selected mutants.
- Results: The study found a low rate of mutants developing resistance, with notable mutants emerging primarily from KPC and AmpC enzymes. Significantly, E. coli showed mutations related to penicillin-binding proteins, suggesting a specific adaptation to ceft
Background: To evaluate, in a cohort study, whether coronary microvasculature and myocardial structure differ between people with and without coronary artery disease (CAD).
Methods And Results: We performed histological analysis of left ventricle free wall obtained at autopsy from 25 men and 23 women with ≥1 coronary artery with ≥75% area stenosis, and 25 men and 25 women without (no or minimal) CAD, matched for sex and age, who died suddenly from noncardiac causes. Decedents with myocardial infarction or other cardiac abnormality were excluded.
Objectives: Since June 2022, there has been a rise in the number of ceftriaxone-resistant Neisseria gonorrhoeae cases detected in England (n = 15), of which a third were XDR. We describe the demographic and clinical details of the recent cases and investigate the phenotypic and molecular characteristics of the isolates. For a comprehensive overview, we also reviewed 16 ceftriaxone-resistant cases previously identified in England since December 2015 and performed a global genomic comparison of all publicly available ceftriaxone-resistant N.
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- The paper discusses the challenges of identifying human remains found at Sandy Point, Victoria, where both circumstantial information and preservation were lacking, complicating the identification process.
- Traditional methods like visual or fingerprint identification were impossible due to the state of the remains, leading to the use of a range of techniques including radiocarbon dating and genetic analysis.
- Ultimately, an interdisciplinary approach combining forensic anthropology, odontology, history, and genealogy successfully identified the remains as belonging to Christopher Luke Moore, who drowned in 1928.
Background: There are varying reports of immunohistochemically detected prostatic marker protein distribution in glands associated with the female urethra that may be related to tissue integrity at the time of fixation.
Aim: In this study we used tissue derived from rapid autopsies of female patients to determine the distribution of glandular structures expressing prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) along the female urethra and in surrounding tissues, including the anterior vaginal wall (AVW).
Methods: Tissue blocks from 7 donors that contained the entire urethra and adjacent AVW were analyzed.