Publications by authors named "N Winn"
Objective: Obesity is a major health concern, largely because it contributes to type 2 diabetes mellitus (T2DM), cardiovascular disease, and various malignancies. Increase in circulating amino acids and lipids, in part due to adipose dysfunction, have been shown to drive obesity-mediated diseases. Similarly, elevated purines and uric acid, a degradation product of purine metabolism, are found in the bloodstream and in adipose tissue.
View Article and Find Full Text PDFEndothelial β1-integrins are necessary for microvascular function and glucose uptake.
Am J Physiol Endocrinol Metab
December 2024
Microvascular insulin delivery to myocytes is rate limiting for the onset of insulin-stimulated muscle glucose uptake. The structural integrity of capillaries of the microvasculature is regulated, in part, by a family of transmembrane adhesion receptors known as integrins, which are composed of an α and a β subunit. The integrin β1 (itgβ1) subunit is highly expressed in endothelial cells (ECs).
View Article and Find Full Text PDFArticle Synopsis
- * Researchers investigated the effects of the PDE-5a inhibitor sildenafil and found that it enhances the benefits of exercise by improving microcirculation and exercise capacity in diet-induced obese mice, but not in sedentary mice.
- * In lean mice with reduced endothelial nitric oxide synthase (eNOS), exercise training still improved endurance, indicating that while eNOS function is important, training alone can lead to significant benefits in microcirculation and exercise performance.
Article Synopsis
- * The study focused on the integrin β1 subunit in endothelial cells, revealing that its absence led to impaired microvascular function and glucose uptake in response to insulin.
- * Findings showed that mice lacking endothelial integrin β1 had decreased capillary flow and density, resulting in compromised insulin-mediated glucose delivery, highlighting its importance for proper muscle function.
Background: Childhood Sjögren's disease is a rare, underdiagnosed, and poorly-understood condition. By integrating machine learning models on a paediatric cohort in the USA, we aimed to develop a novel system (the Florida Scoring System) for stratifying symptomatic paediatric patients with suspected Sjögren's disease.
Methods: This cross-sectional study was done in symptomatic patients who visited the Department of Pediatric Rheumatology at the University of Florida, FL, USA.