Publications by authors named "N Winer"
Background: Preeclampsia (PE) contributes to maternal and fetal mortality and morbidity. Supplementation with L-arginine, the precursor of nitric oxide, has not proven effective, possibly due to extensive arginine catabolism in the splanchnic bed. Citrulline is converted by the kidney to L-arginine.
View Article and Find Full Text PDFArticle Synopsis
- ARID1A and ARID1B duplications are linked to Coffin-Siris syndrome, but ARID1B duplications have not been previously associated with a specific clinical phenotype until now.
- A study analyzed 16 cases of ARID1A and 13 cases of ARID1B duplications, revealing that ARID1A duplications resulted in more severe symptoms, including intellectual disabilities and growth delays, while both groups displayed similar features.
- The research identified unique DNA methylation patterns in ARID1A duplication patients, which differ from those with loss-of-function variants, suggesting the presence of a distinct clinical phenotype for both ARID1A and ARID1B duplications, indicating a new type of
Article Synopsis
- The study compared dinoprostone vaginal insert (PG) and cervical ripening balloon (CRB) for cervical ripening in women at term with an unfavorable cervix after initial PG treatment.
- A total of 180 women were assessed, revealing that 93.3% achieved a favorable cervix or entered labor within 24 hours after the second device, with CRB showing a significantly higher success rate than repeated PG.
- While vaginal delivery rates and neonatal morbidity were similar between the two groups, CRB was more effective in improving cervix status compared to repeated PG in the study population.
Article Synopsis
- Preterm premature rupture of membranes (PPROM) causes 1-3% of premature deliveries, and while conventional hospitalization (CH) is common, homecare (HC) may also be a viable option.* -
- The study compared the impacts of HC and CH on the latency period for pregnant patients experiencing PPROM, revealing that HC patients had a significantly longer latency period and higher latency ratio.* -
- Results indicated that HC can be beneficial for stable patients, as the latency period was longer in the HC group compared to the CH group, suggesting that HC may optimize outcomes for certain patients.*
Article Synopsis
- A study was conducted to compare perinatal outcomes between immediate and deferred selective termination of discordant twin pregnancies with anomalies, considering the risk of pregnancy loss.
- The results showed that the deferred selective termination group had a 100% survival rate for the healthy co-twin, while the immediate group had a 93.8% survival rate (P<.01).
- Additionally, the rate of preterm birth was significantly lower in the deferred group (20.2%) compared to the immediate group (66.7%), indicating more favorable outcomes with delayed procedures.*