Publications by authors named "N Willumsen"
Purpose: There is an unmet need for new treatment options and biomarkers for patients with glioblastoma (GBM). Here we investigated three non-invasive biomarkers: type VI collagen degraded by granzyme B (C4G) and matrix metalloproteases (C4M), respectively, and ADAM10-degraded Tau (Tau-A).
Methods: Biomarker levels in pre- and on-treatment serum samples from patients with recurrent GBM (n = 39) treated with nivolumab and bevacizumab (NCT03890952) were compared to healthy levels (n = 22) and associated with overall survival (OS) outcome (median cutpoint).
Article Synopsis
- Genetic variants in the tau gene have been linked to increased risk for Alzheimer's disease (AD) and other neurodegenerative disorders, with specific haplotypes H1 and H2 thought to contribute to these risks.
- The study analyzed 964 individuals, including those with AD, mild cognitive impairment, other dementias, and healthy controls, to assess the impact of certain polymorphisms on cognitive performance.
- Key findings showed that certain alleles and haplotypes were associated with poorer cognitive test results and pathological levels of cerebrospinal fluid biomarkers, indicating a complex relationship between genetic factors and AD, necessitating further research.
Understanding the tumor microenvironment (TME) and extracellular matrix (ECM) is crucial in cancer research due to their impact on tumor progression. Collagens, major ECM components, regulate cell signaling and behavior. Of the 28 reported collagens, type XII collagen is known to be vital for ECM organization.
View Article and Find Full Text PDFThe fibrotic tumor microenvironment, characterized by its intricate extracellular matrix (ECM), consists of many collagens with diverse functions and unexplored biomarker potential. Type IX collagen is a member of the low-abundance collagen family known as the fibril-associated collagen with interrupted triple helices (FACITs) and is found mostly in cartilage. Its role in the tumor microenvironment remains unexplored.
View Article and Find Full Text PDFAging is associated with cell senescence and is the major risk factor for AD. We characterized premature cell senescence in postmortem brains from non-diseased controls (NDC) and donors with Alzheimer's disease (AD) using imaging mass cytometry (IMC) and single nuclear RNA (snRNA) sequencing (> 200,000 nuclei). We found increases in numbers of glia immunostaining for galactosidase beta (> fourfold) and p16 (up to twofold) with AD relative to NDC.
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