Publications by authors named "N Weis"

The global strategy to eradicate Hepatitis B (HBV), Hepatitis C (HCV), and HIV by 2030 is critical due to their impact and challenges to healthcare systems. HCV is curable, but HBV and HIV are only suppressible, with a vaccine available solely for HBV. Innovative diagnostic methods are needed, especially for high-risk populations like people who inject drugs (PWID).

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Background: Diaphorina citri is an insect vector of "Candidatus Liberibacter asiaticus" (CLas), the gram-negative bacterial pathogen associated with citrus greening disease. Control measures rely on pesticides with negative impacts on the environment, natural ecosystems, and human and animal health. In contrast, gene-targeting methods have the potential to specifically target the vector species and/or reduce pathogen transmission.

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Objective: To investigate the use of non-barrier contraceptives among women with HIV (WWH) compared to women from the general population (WGP) in Denmark.

Design: Nationwide population-based matched cohort study.

Methods: We included WWH aged 16-50, treated at an HIV specialized clinic, and included in The Danish HIV Cohort Study between 1995-2021 and an age-matched comparison cohort of WGP.

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Article Synopsis
  • Recent guidelines for women living with HIV in high-income countries emphasize shared decision-making, yet there's limited understanding of their infant feeding knowledge and healthcare provider interactions.
  • This study, conducted in Denmark, Finland, and Sweden, involved pregnant women living with HIV, gathering both quantitative data through a survey and qualitative insights from interviews to explore their knowledge and experiences over time.
  • Results revealed that women were confused about breastfeeding in relation to the U=U concept, with Nordic women showing more uncertainty than those from non-Nordic backgrounds, while ongoing monitoring of mothers was not perceived as a barrier to breastfeeding.
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Article Synopsis
  • The evolution of SARS-CoV-2 has resulted in several variants of concern (VOCs), especially omicron sub-lineages, which display resistance to neutralizing antibodies from past infections or vaccinations.
  • In this study, researchers created various mutant viruses with spike protein changes from VOCs like omicron JN.1, and analyzed their resistance to neutralization using plasma from recovered and vaccinated individuals.
  • Findings revealed that while specific changes in the spike receptor binding domain contribute to resistance, alterations outside this region are also important; additionally, some omicron variants showed a reduced reliance on the ACE2 receptor for viral entry but maintained increased binding affinity for it.
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