Publications by authors named "N Wasenius"
Article Synopsis
- This study examined how variations in a specific polygenic risk score related to brain insulin receptors are linked to frailty over time.
- During the research involving 1,605 participants, it was found that women generally exhibited higher frailty levels than men, particularly those with a high risk score in the hippocampus.
- The results suggest that understanding this genetic variation could lead to new strategies for treating frailty and age-related issues.
Introduction: Few studies have investigated the association between frailty and subsequent body composition.
Methods: We performed separate linear mixed model analyses to study the associations between changes in the participant frailty status assessed by a frailty index (FI) and subsequent body mass index (BMI), lean mass index (LMI), fat mass index (FMI), and FMI to LMI ratio values assessed on three occasions over 17 years. The analyses were carried out among 996 participants spanning from age 57 to 84 years.
Background: Few studies have examined longitudinal changes in lifestyle-related factors and frailty.
Methods: We examined the association between individual lifestyle factors (exercise, diet, sleep, alcohol, smoking and body composition), their sum at baseline, their change over the 17-year follow-up and the rate of change in frailty index values using linear mixed models in a cohort of 2,000 participants aged 57-69 years at baseline.
Results: A higher number of healthy lifestyle-related factors at baseline was associated with lower levels of frailty but not with its rate of change from late midlife into old age.
Objectives: Changes in socioeconomic status (SES) during life may impact health in old age. We investigated whether social mobility and childhood and adulthood SES are associated with trajectories of health-related quality of life (HrQoL) over a 17-year period.
Methods: We used data from the Helsinki Birth Cohort Study ( = 2003, 46% men, mean age 61.