Publications by authors named "N Wallis"
Article Synopsis
- Individuals at ultra-high risk (UHR) for psychosis with persistent attenuated psychotic symptoms (APS) show worse clinical and functional outcomes compared to those who remit, closely resembling individuals who transition to psychosis.
- After an initial period, the symptom and functioning trajectories for those with persistent APS diverge quickly from those who remit.
- Prediction of non-remission improves significantly with longitudinal data (6-month follow-up) rather than relying on baseline data alone, indicating the need for consistent monitoring and intervention for UHR individuals with persistent APS.
Background: Since the late 1990s, there has been a worldwide surge of scientific interest in the pre-psychotic phase, resulting in the introduction of several clinical tools for early detection. The predictive accuracy of these tools has been limited, motivating the need for methodological and perspectival improvements. The EASE manual supports systematic assessment of anomalous self-experience, and proposes an overall model of understanding how most psychotic experiences may be initially generated on the basis of a unifying, fundamental, pre-reflective distortion of subjectivity.
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- Colombia faces high levels of internal displacement, with one in three displaced women experiencing adolescent pregnancy, highlighting significant health and resource disparities compared to the general population.
- The study used qualitative methods to interview 14 participants, including displaced women and their mothers, focusing on the impacts of structural violence in their experiences with early childbearing.
- Findings reveal that while pregnancy can provide a sense of security for these women, it also brings significant disadvantages, such as poverty, discrimination, and limited access to healthcare and education, underscoring the need for context-sensitive policies.
β-Glucocerebrosidase (GBA/GCase) mutations leading to misfolded protein cause Gaucher's disease and are a major genetic risk factor for Parkinson's disease and dementia with Lewy bodies. The identification of small molecule pharmacological chaperones that can stabilize the misfolded protein and increase delivery of degradation-prone mutant GCase to the lysosome is a strategy under active investigation. Here, we describe the first use of fragment-based drug discovery (FBDD) to identify pharmacological chaperones of GCase.
View Article and Find Full Text PDFDecreased white matter (WM) integrity and disturbance in fatty acid composition have been reported in individuals at ultra-high risk of psychosis (UHR). The current study is the first to investigate both WM integrity and erythrocyte membrane polyunsaturated fatty acid (PUFA) levels as potential risk biomarkers for persistent UHR status, and global functioning in UHR individuals. Forty UHR individuals were analysed at baseline for erythrocyte membrane PUFA concentrates.
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