Publications by authors named "N W Treister"
Rejection monitoring in facial vascularized composite allotransplantation (fVCA) traditionally focuses on skin biopsies. However, mucosal rejection frequently presents with more pronounced signs of immune activity. To explore mechanistic differences between skin and mucosal rejection, rejection and non-rejection biopsies from allograft skin and oral mucosa of nine fVCA recipients were retrospectively analyzed using histology, multiplex immunostaining, and gene expression profiling, with peripheral blood mononuclear cells (PBMCs) quantified via mass cytometry (CyTOF).
View Article and Find Full Text PDFCancer presents a significant global health burden. Traditional treatment modalities, especially radiotherapy and chemotherapy, have improved survival, but they have long-term consequences. Treatment-induced malignancies, a growing concern, pose risks to survivors.
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- * The condition starts when the transplanted cells recognize the recipient's body as foreign, leading to inflammatory responses and potential organ damage.
- * This review covers the latest understanding of cGvHD's development, diagnosis, and treatment options, highlighting new therapies and insights from clinical research and expert opinions.
Article Synopsis
- Oral chronic graft-versus-host disease (cGVHD) can lead to various symptoms affecting the mouth, contributing to a lower quality of life for patients.
- Symptoms can include changes in the oral mucosa, reduced saliva production, and issues with surrounding soft tissues.
- The review aims to offer a straightforward guide for diagnosing and managing oral health problems in both pediatric and adult patients who have received allogeneic hematopoietic cell transplantation (alloHCT) within the first two years after their procedure.