Autoimmune diseases often exhibit a preclinical stage before diagnosis. Electronic health record (EHR) based-biobanks contain genetic data and diagnostic information, which can identify preclinical individuals at risk for progression. Biobanks typically have small numbers of cases, which are not sufficient to construct accurate polygenic risk scores (PRS).
View Article and Find Full Text PDFAims: This study tested the efficacy and safety of a 12-week course of lisdexamfetamine in reducing methamphetamine use, an outcome which is associated with improvements in health and wellbeing, in people dependent on methamphetamine.
Design, Setting And Participants: This study was a randomised double-blind placebo-controlled trial conducted in six specialist outpatient clinics in Adelaide, Melbourne, Newcastle and Sydney, Australia (2018-2021). Participants were164 adults with methamphetamine dependence, reporting at least 14 use days out of the previous 28 days (62% male, 38% female, < 1% other; mean age 39 years).
Philos Trans A Math Phys Eng Sci
December 2024
The tidal flow of seawater across the Earth's magnetic field induces electric currents and magnetic fields within the ocean and solid Earth. The amplitude and phase of the induced fields depend on the electrical properties of both seawater and the solid Earth, and thus can be used as proxies to study the seabed properties or potentially for monitoring long-term trends in the global ocean climatology. This article presents new global oceanic tidal magnetic field models and their uncertainties for four tidal constituents, including [Formula: see text] and even [Formula: see text], which was not reliably retrieved previously.
View Article and Find Full Text PDF