Publications by authors named "N W J Bulkmans"
Objectives: Evaluating invasion in non-mucinous adenocarcinoma (NMA) of the lung is crucial for accurate pT-staging. This study compares the World Health Organization (WHO) with a recently modified NMA classification.
Materials And Methods: A retrospective case-control study was conducted on small NMA pT1N0M0 cases with a 5-year follow-up.
Background: The TNM (tumor-node-metastasis) Evaluation Committee of Union for International Cancer Control (UICC) and College of American Pathologists (CAP) recommended to prospectively validate the cost-effective and robust tumor-stroma ratio (TSR) as an independent prognostic parameter, since high intratumor stromal percentages have previously predicted poor patient-related outcomes.
Patients And Methods: The 'Uniform Noting for International application of Tumor-stroma ratio as Easy Diagnostic tool' (UNITED) study enrolled patients in 27 participating centers in 12 countries worldwide. The TSR, categorized as stroma-high (>50%) or stroma-low (≤50%), was scored through standardized microscopic assessment by certified pathologists, and effect on disease-free survival (DFS) was evaluated with 3-year median follow-up.
Objectives: Programmed death-ligand 1 (PD-L1) is the only approved predictive biomarker for immunotherapy in non-small cell lung cancer (NSCLC). However, predictive PD-L1 immunohistochemistry is subject to interobserver variability. We hypothesized that a pathologist's personality influences the interobserver variability and diagnostic accuracy of PD-L1 immunoscoring.
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- The text refers to a correction made to the scientific article identified by the DOI 10.1371/journal.pone.0223827.* -
- This correction likely addresses errors or changes in the original publication to ensure accurate information is presented.* -
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Article Synopsis
- * Researchers examined 139 tumor pairs from 90 patients, finding that 53% showed clonal relationships, while a significant portion (24%) was non-clonal, highlighting complexities in tumor classification.
- * The findings suggest that while there is some agreement between histological assessments and CNA results, comprehensive genetic testing may be more reliable for determining the nature of a second tumor, influencing treatment decisions.