Infertility associated with luteal phase defect.

Infertility, either primary or secondary, affects approximately 15% of the population of childbearing age. Luteal phase defect, a deficiency of corpus luteum progesterone steroidogenisis, is noted in cases of primary infertility and in approximately 35% of couples who have experienced recurrent miscarriage. Supplemental progesterone therapy before implantation and continued into early pregnancy helps these couples to achieve a successful pregnancy outcome.