Publications by authors named "N Vuckovic"
: Although BRAF inhibitors, such as vemurafenib, produce a marked response in patients with advanced melanoma with a BRAF V600 mutation, they eventually develop resistance to this treatment. To address this issue, vemurafenib is increasingly combined with the MEK inhibitor cobimetinib, leading to improved response rates and enhanced survival. However, this treatment modality is associated with numerous side effects.
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- - Botryosphaeria dothidea is mainly known for causing diseases in woody plants, like stem canker and dieback, but has also been linked to damaging field crops such as soybeans, tobacco, and sugar beets.
- - In a survey conducted in Serbia in September 2023, 3% of sugar beet samples showed severe root rot symptoms, with dark brown lesions and completely rotted roots indicating possible infection by B. dothidea.
- - Two fungal isolates were obtained and identified through their growth characteristics and DNA analysis, confirming their identity as B. dothidea, consistent with previously documented descriptions of the pathogen.
Article Synopsis
- Postoperative delirium remains common after surgery, prompting ongoing research to find effective interventions despite mixed results from trials.
- A total of 201 trials were analyzed, revealing that trials conducted in the USA/Canada and Europe had higher odds ratios, indicating lower effectiveness compared to those from China.
- The study emphasizes that the incidence of delirium, regional differences, and potential biases significantly influence trial outcomes, suggesting a need for better-quality global research on this issue.
In Europe, two fastidious phloem-limited pathogens, 'Candidatus Phytoplasma solani' (16SrXII-A) and 'Candidatus Arsenophonus phytopathogenicus', are associated with rubbery taproot disease (RTD) and syndrome basses richesses (SBR) of sugar beet, respectively. Both diseases can significantly reduce yield, especially when accompanied by root rot fungi. This study investigates the presence, geographic distribution and genetic traits of fastidious pathogens and the accompanying fungus, Macrophomina phaseolina, found on sugar beet across four geographically separated plains spanning seven countries in Central Europe.
View Article and Find Full Text PDFCervical cancer is the fourth leading cause of cancer deaths in women, with over 340,000 women dying from this disease in 2020. Almost all cases have an underlying persistent infection with an oncogenic high-risk type of human papillomavirus (HPV), mainly HPV16. While cervical squamous cell carcinoma is hardly ever HPV-negative, a small subset of adenocarcinoma exhibits absence of HPV, even after disproval of false-negative testing results due to low viral load.
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