Publications by authors named "N Vrkic"
Article Synopsis
- - The study investigated the link between specific genetic variations (polymorphisms) in the TNF-α gene and clinical outcomes in patients with inflammatory bowel diseases (IBD) and immune-mediated rheumatic diseases (IMRD), focusing on markers like C-reactive protein (CRP) and fecal calprotectin (fCAL).
- - Results indicated that while the TNF-α -308 GG genotype was associated with higher levels of CRP and fCAL in IBD patients undergoing treatment with anti-TNF inhibitors, there was no significant relationship between the genotypes and rates of clinical remission or the development of anti-drug antibodies.
- - Overall, the study concludes that the TNF-α -308 GG genotype
Article Synopsis
- * Over a 9-month treatment period, blood levels of GAD65 autoantibodies decreased by approximately 25%.
- * The results suggest that Boswellia serrata may help prevent insulitis in LADA patients, warranting further research and clinical trials to assess its potential benefits on autoimmune diabetes.
Vitamin D is beneficial in patients with immune-mediated rheumatic diseases as it has been shown that it lowers the incidence risk and the level of inflammation. To examine the association between clinical outcomes and initial 25-hydroxyvitamin D [25(OH)D] concentrations in patients with the immune-mediated rheumatic diseases treated with infliximab for 9 months. This study was performed in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) treated with infliximab for at least 38 weeks.
View Article and Find Full Text PDFDetecting predictors of poor outcome is crucial for understanding the underlying pathophysiology of heart failure (HF) and thus creating new therapeutic concepts. It is well established that low serum lipid levels are associated with unfavorable outcomes in HF patients. Several studies examined the association between serum lipids and established predictors of mortality in HF patients.
View Article and Find Full Text PDFObjective: The objective of the research was to evaluate diagnostic and predictive value for determination of KFLC in cerebrospinal fluid (CSF) compared to the qualitative procedure of OCB determination in patients with CIS who converted to MS during a two-year period.
Patients And Methods: KFLC, total immunoglobulin G (IgG), serum albumin and CSF albumin were determined with an immunonephelometric method in 151 patients with suspected MS who were admitted to the Neurology Clinic while CSF/serum quotients (QKFLC, QIgG and QAlb) and indexes were calculated with regards to albumin (QCSF/Qserum). Presence of OCBs was determined by isoelectric focusing with immunofixation.