Publications by authors named "N Volkan Adsay"

Inactivating alterations in the SWItch/Sucrose NonFermentable (SWI/SNF) Chromatin Remodeling Complex subunits have been described in multiple tumor types. Recent studies focused on SMARC subunits of this complex to understand their relationship with tumor characteristics and therapeutic opportunities. To date, pancreatic cancer with these alterations has not been well studied, although isolated cases of undifferentiated carcinomas have been reported.

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Article Synopsis
  • A study analyzed 69 pancreatic intraductal papillary neoplasms (IPNs) and various related samples, identifying over 10,000 proteins and 22,000 glycopeptides using mass spectrometry.
  • *Among these, 756 proteins showed increased abundance in IPNs compared to normal pancreatic ducts, with 45% also found in cyst fluids.
  • *The research also distinguished two subtypes of IPMs and highlighted potential targets for earlier detection and treatment of pancreatic cancer.*
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Background: Grade 1/2 PanNETs are mostly managed similarly, typically without any adjunct treatment with the belief that their overall metastasis rate is low. In oncology literature, Ki67-index of 10% is increasingly being used as the cutoff in stratifying patients to different protocols, although there are no systematic pathology-based studies supporting this approach.

Methods: Ki67-index was correlated with clinicopathologic parameters in 190 resected PanNETs.

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The guidelines recently recognized the intra-ampullary papillary tubular neoplasm (IAPN) as a distinct tumor entity. However, the data on IAPN and its distinction from other ampullary tumors remain limited. A detailed clinicopathologic analysis of 72 previously unpublished IAPNs was performed.

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