Publications by authors named "N Vilor-Tejedor"
Background: While numerous studies have identified blood proteins that modulate brain aging in mice, the direct translation of these findings to human health remains a substantial challenge. Bridging this gap is critical for developing interventions that can effectively target human brain aging and associated diseases.
Methods: We first identified 12 proteins with aging or rejuvenating properties in murine brains through a systematic review.
Several studies have identified blood proteins that influence brain aging performance in mice, yet translating these findings to humans remains challenging. Here we found that higher predicted plasma levels of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) were significantly associated with improved global cognition and memory performance in humans. We first identified 12 proteins with aging or rejuvenating effects on murine brains through a systematic review.
View Article and Find Full Text PDFStructural Brain Differences in the Alzheimer's Disease Continuum: Insights Into the Heterogeneity From a Large Multisite Neuroimaging Consortium.
Biol Psychiatry Cogn Neurosci Neuroimaging
July 2024
Background: Neurodegenerative diseases require collaborative, multisite research to comprehensively grasp their complex and diverse pathological progression; however, there is caution in aggregating global data due to data heterogeneity. In the current study, we investigated brain structure across stages of Alzheimer's disease (AD) and how relationships vary across sources of heterogeneity.
Methods: Using 6 international datasets (N > 27,000), associations of structural neuroimaging markers were investigated in relation to the AD continuum via meta-analysis.
Article Synopsis
- The study explores the genetic risk factors for Alzheimer's disease (AD) and their connection to various brain changes, aiming to enhance precision medicine strategies.
- Researchers calculated specific genetic risk scores in healthy individuals to see how these scores correlate with AD-related biomarkers found in cerebrospinal fluid and imaging techniques.
- Findings show that different genetic pathways link to distinct brain conditions, such as inflammation affecting vascular health and other pathways influencing white matter and brain connectivity, highlighting the complexity of AD and its potential for personalized treatment approaches.
Introduction: We examined whether baseline glial markers soluble triggering receptor expressed on myeloid cell 2 (sTREM2), chitinase 3-like protein 1 (YKL-40), and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF), and plasma GFAP are associated with cognitive change in cognitively unimpaired (CU) individuals at risk of Alzheimer's disease (AD).
Methods: A total of 353 CU (mean age 60.9 years) participants were included (mean follow-up time 3.