Publications by authors named "N Vilarino"
Article Synopsis
- Cyanobacterial blooms, driven by eutrophication and climate change, are increasing cyanotoxin levels in water, creating public health risks due to ineffective removal by current water treatment plants.
- This study proposes a novel treatment using nanostructured beads with magnetic nanoparticles and various adsorbent materials to target cyanotoxins like microcystin-LR, cylindrospermopsin, and anatoxin-A.
- Results showed two particle types effectively removed these toxins without harming human cell viability, suggesting this approach could be a safe and effective solution, although more research is needed.
Article Synopsis
- There is an increasing concern about ciguatera fish poisoning due to the rise of ciguatoxin-producing microorganisms, necessitating a fast and reliable detection method for ciguatoxins to ensure food safety.
- The study evaluated various cell lines for their effectiveness in ciguatoxin detection, highlighting issues with the standard N2a cell line, which showed low sodium channel availability and high sensitivity to chemicals used for sensitization.
- The HEK293 Nav cell line, expressing specific sodium channel subunits, was identified as a suitable alternative for detecting ciguatoxins, enabling detection down to very low concentrations without the need for prior sensitization.
Brevetoxins (PbTxs) are emerging marine toxins that can lead to Neurotoxic Shellfish Poisoning in humans by the ingestion of contaminated seafood. Recent reports on brevetoxin detection in shellfish in regions where it has not been described before, arise the need of updated guidelines to ensure seafood consumers safety. Our aim was to provide toxicological data for brevetoxin 3 (PbTx3) by assessing oral toxicity in mice and comparing it with intraperitoneal administration.
View Article and Find Full Text PDFLung adenocarcinoma (LUAD) is a molecularly heterogeneous disease. In addition to genomic alterations, cancer transcriptional profiling can be helpful to tailor cancer treatment and to estimate each patient's outcome. Transcriptional activity levels of 50 molecular pathways were inferred in 4573 LUAD patients using Gene Set Variation Analysis (GSVA) method.
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