Publications by authors named "N Viguerie"
Article Synopsis
- Type 2 diabetes (T2D) and obesity are linked to low levels of natriuretic peptide (NP) and reduced NP guanylyl cyclase receptor-A (GCA) in muscles and fat tissue.
- Research in mice shows that lack of ANP/GCA leads to metabolic issues and prediabetes, causing insulin resistance and poor endurance.
- ANP/GCA is crucial for maintaining mitochondrial function and oxidative capacity in skeletal muscle, suggesting it plays a key role in the development of prediabetes.
Obesity is associated with the development of local adipose tissue (AT) and systemic inflammation. Most adipokines are upregulated with obesity and have pro-inflammatory properties. Few are downregulated and possess beneficial anti-inflammatory effects.
View Article and Find Full Text PDFGrowth and differentiation factor 15 (GDF15) has recently emerged as a weight loss and insulin-sensitizing factor. Growing evidence also supports a role for GDF15 as a physiological, exercise-induced stress signal. Here, we tested whether GDF15 is required for the insulin-sensitizing effects of exercise in mice and humans.
View Article and Find Full Text PDFThe 5/6 nephrectomy and adenine-induced nephropathy mouse models have been extensively used to study Chronic Kidney Disease (CKD)-related cachexia. One common caveat of these CKD models is the cross-sectional nature of comparisons made versus controls. We here performed a comprehensive longitudinal assessment of body composition and energy metabolism in both models.
View Article and Find Full Text PDFArticle Synopsis
- In a study of over 3,000 people, researchers found that men are more insulin resistant than women, especially when they are obese.
- They looked at how fat cells respond to insulin, finding that men’s fat cells didn't respond as well as women's when it came to breaking down fat.
- The study also showed that a specific gene related to insulin (called IRS1) was more active in women, which might help explain why women are better at managing their insulin compared to men.