Publications by authors named "N Vigneron"
Background: Priming plants with natural products is extensively studied in the agricultural field to reduce the use of synthetic and copper-based pesticides. Previous studies have shown that Oregano essential oil vapour (OEOV) is an effective priming agent against downy mildew (DM) in grapevine (Vitis vinifera L. cv.
View Article and Find Full Text PDFDendritic cells (DCs) are critical players at the intersection of innate and adaptive immunity, making them ideal candidates for anticancer vaccine development. DC-based immunotherapies typically involve isolating patient-derived DCs, pulsing them with tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs), and utilizing maturation cocktails to ensure their effective activation. These matured DCs are then reinfused to elicit tumor-specific T-cell responses.
View Article and Find Full Text PDFArticle Synopsis
- Melanoma antigen gene (MAGE)-type antigens are effective targets for cancer immunotherapy, as they appear in cancer cells but not in normal tissues, with the exception of some male germline cells.
- Researchers focused on the mouse P1A antigen, identifying a specific CD8 T-cell epitope presented by the H-2D molecule in C57BL/6 mice, using adenovirus and modified vaccinia Ankara vaccines to enhance immune responses.
- The study successfully induced a strong immune response targeting a specific 9-amino acid peptide from the P1A antigen, leading to protection against specific tumors and the identification of T-cell receptors (TCRs) that could be used for adoptive cell therapy.
Background: The impact of geographical accessibility on cancer survival has been investigated in few studies, with most research focusing on access to reference care centers, using overall mortality and limited to specific cancer sites. This study aims to examine the association of access to primary care with mortality in excess of patients with the 10 most frequent cancers in France, while controlling for socioeconomic deprivation.
Methods: This study included a total of 151,984 cases diagnosed with the 10 most common cancer sites in 21 French cancer registries between 2013 and 2015.
Article Synopsis
- Ovarian cancer, a leading cause of gynecological cancer deaths, often becomes resistant to chemotherapy, highlighting the urgency for new treatment approaches and predictive biomarkers.
- The OVAREX study investigates the feasibility of creating patient-derived tumor models (like PDX, PDTO, and ADS) to predict clinical outcomes for ovarian cancer patients undergoing treatment.
- This research aims to validate the predictive capabilities of these models by comparing their responses to treatments with actual patient outcomes, potentially enhancing clinical decision-making.