Publications by authors named "N Venteclef"
The mechanisms governing adipose tissue macrophage (ATM) metabolic adaptation during diet-induced obesity (DIO) are poorly understood. In obese adipose tissue, ATMs are exposed to lipid fluxes, which can influence the activation of specific inflammatory and metabolic programs and contribute to the development of obesity-associated insulin resistance and other metabolic disorders. In the present study, we demonstrate that the membrane ATP-binding cassette g1 (Abcg1) transporter controls the ATM functional response to fatty acids (FAs) carried by triglyceride-rich lipoproteins, which are abundant in high-energy diets.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the role of the enzyme ELOVL5 in the biosynthesis of Polyunsaturated Fatty Acids (PUFAs) and its implications for liver conditions, specifically MASH (metabolic-associated steatotic liver disease), revealing how enzyme disruption affects liver metabolism.
- - Research showed that ELOVL5 levels increase during MASH progression and that its absence in mice leads to significant liver issues after a high-fat, high-sucrose diet, including fat accumulation, inflammation, and fibrosis.
- - The findings suggest that the loss of ELOVL5 disrupts mitochondrial function, contributes to liver damage from dietary factors, and alters fatty acid metabolism, indicating a critical link between enzyme activity and liver health.
Immunometabolic Rewiring: A Tale of Macronutrients and Macrophages.
Results Probl Cell Differ
October 2024
Myeloid cells, including monocytes, macrophages, dendritic cells, and polymorphonuclear cells are key components of homeostasis maintenance and immune response. Among the myeloid lineage, macrophages stand out as highly versatile cells that safeguard tissue functions but also sense and respond to potentially harmful microenvironmental cues. Numerous studies have demonstrated that the nutritional status and macronutrient availability affect macrophage identity and function.
View Article and Find Full Text PDFThe liver macrophage population comprises resident Kupffer cells (KCs) and monocyte-derived macrophages with distinct pro- or anti-inflammatory properties that affect the severity and course of liver diseases. The mechanisms underlying macrophage differentiation and functions in metabolic dysfunction-associated steatotic liver disease and/or steatohepatitis (MASLD/MASH) remain mostly unknown. Using single-cell RNA sequencing (scRNA-seq) and fate mapping of hepatic macrophage subpopulations, we unraveled the temporal and spatial dynamics of distinct monocyte and monocyte-derived macrophage subsets in MASH.
View Article and Find Full Text PDFFully automated epicardial adipose tissue volume quantification with deep learning and relationship with CAC score and micro/macrovascular complications in people living with type 2 diabetes: the multicenter EPIDIAB study.
Cardiovasc Diabetol
September 2024
Background: The aim of this study (EPIDIAB) was to assess the relationship between epicardial adipose tissue (EAT) and the micro and macrovascular complications (MVC) of type 2 diabetes (T2D).
Methods: EPIDIAB is a post hoc analysis from the AngioSafe T2D study, which is a multicentric study aimed at determining the safety of antihyperglycemic drugs on retina and including patients with T2D screened for diabetic retinopathy (DR) (n = 7200) and deeply phenotyped for MVC. Patients included who had undergone cardiac CT for CAC (Coronary Artery Calcium) scoring after inclusion (n = 1253) were tested with a validated deep learning segmentation pipeline for EAT volume quantification.