Publications by authors named "N Vaziri"
Objective: This study was designed to determine the effect of 16 weeks of supplementation with Hi-maize 260 resistant starch (RS) on the gut microbiota, uremic toxins (indoxyl sulfate and p-cresyl sulfate [PCS]), markers of inflammation, and oxidative stress along with vascular function in patients with stage G3a-G4 chronic kidney disease (CKD).
Design And Methods: This was a double-blind, placebo-controlled, parallel-arm, randomized controlled trial. Sixty-eight patients with stage-G3a-G4 CKD were randomized to either RS with usual care or placebo and usual care.
Antipsychotic medications are essential when treating schizophrenia spectrum and other psychotic disorders, but the efficacy and tolerability of these medications vary from person to person. This interindividual variation is likely mediated, at least in part, by epigenomic processes that have yet to be fully elucidated. Herein, we systematically identified and evaluated 65 studies that examine the influence of antipsychotic drugs on epigenomic changes, including global methylation (9 studies), genome-wide methylation (22 studies), candidate gene methylation (16 studies), and histone modification (18 studies).
View Article and Find Full Text PDFTargeting Lactobacillus johnsonii to reverse chronic kidney disease.
Signal Transduct Target Ther
August 2024
Article Synopsis
- Research suggests that gut microbial imbalance (dysbiosis) contributes to the worsening of chronic kidney disease (CKD), but there is currently no effective treatment available.
- A specific bacteria, Lactobacillus johnsonii, is linked to CKD progression; its levels decrease in CKD cases, and supplementation with this bacteria improved kidney damage in animal studies.
- The study finds that a compound called indole-3-aldehyde (IAld), which correlates with kidney health, can help protect against kidney damage by interacting with specific cellular pathways, suggesting that increasing levels of L. johnsonii may offer new treatment options for CKD patients.
Article Synopsis
- - Ramadan fasting is a significant Islamic practice, but patients with a history of metabolic/bariatric surgery (MBS) may face unique risks, highlighting the need for better guidance and recommendations regarding fasting safety.
- - An international survey involving 21 medical centers across 11 countries identified 132 patients who experienced complications while fasting post-MBS, with upper gastrointestinal (GI) issues being the most common.
- - Complications such as GERD, abdominal pain, and dumping syndrome were reported, and surgical intervention was required for a small percentage of patients; hence, it's crucial to inform MBS patients about potential risks during fasting and to review their medications.
Antipsychotic drug-induced myocarditis is a serious and potentially fatal adverse drug reaction characterized by inflammation of the heart muscle (myocardium) that typically develops within the first month after commencing an antipsychotic drug. Although the precise mechanism of this severe adverse drug reaction is unknown, multiple theories have been proposed with varying levels of support from cellular or animal studies. We conducted a systematic review, in accordance with PRISMA guidelines, of published preclinical and clinical studies investigating the cellular mechanism by which antipsychotic drugs induce myocarditis.
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