[The effect of contaminants on characteristics of 99mTC radiopharmaceuticals].

The influence of 99Tc, oxygen and cupric ions on labeling yield of eight radiopharmaceuticals was examined. The results obtained for commercial and experimental preparations were compared. The latter were formulated so that the content of 99Tc was 4 times, hydrogen peroxide 5 times and copper 50 times higher than in commercial preparations.

Labelling of leukocytes with 99mTc-HMPAO for scintigraphy of inflammatory lesions and abscesses.

A simplified and efficient procedure for 99mTc-HMPAO-labelling of leukocytes is described. For this purpose, the pH and concentration of the 99mTc-HMPAO preparation was modified. Leukocytes were isolated from a 20 mL mixture of patient blood, 5 mL ACD and 0.

Studies of the chemical and biological properties of the liver-imaging agent 99mTc-phytate.

The correlation between chemical formulation and biodistribution of 99mTc-phytate solutions was examined. On the basis of radiochemical analyses and biological experiments, the following optimum parameters were found: weight ratio of the anhydrous sodium phytate to SnCl2 18:1; concentration of phytate 5-6 g/l, pH of the injection solution 6-7. Maximum uptakes in rat organs were in the liver 95.

Biochemical studies of the renal radiopharmaceutical compound dimercaptosuccinate. IV. Interaction of 99mTc-DMS and 99Tc-DMS complexes with blood serum proteins.

As a crucial step towards understanding the mechanism of localisation of radiopharmaceuticals in specific target organs, the interaction of the radiopharmaceuticals 99mTc-DMS and 99Tc-DMS with blood serum proteins was studied. The interaction of 99mTc-DMS radiopharmaceutical was examined from two aspects: total protein binding as well as specificity of binding to certain classes of proteins. After in vitro labelling of human sera with 99mTc-DMS, the following values of bound radioactivity to total serum proteins were determined: 65% +/- 3.