Publications by authors named "N Van de Kar"
In treating type 2 diabetes, avoiding glucose reabsorption (glucotoxicity) and managing hyperglycemia are also important. A metabolic condition known as diabetes (type-2) is characterized by high blood sugar levels in comparison to normal Bilosomes (BLs) containing Dapagliflozin (Dapa) were formulated, optimized, and tested for oral therapeutic efficacy in the current investigation. Used the Box Behnken design to optimize the Dapa-BLs, formulated via a thin-film hydration technique.
View Article and Find Full Text PDFSepsis is a leading cause of neonatal morbidity and mortality worldwide, especially in low- and middle- income countries (LMIC). It is estimated to cause almost 1 million deaths that accounts for more than 25.0% of neonatal deaths worldwide.
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- Neurological disorders (NDs) like Alzheimer's, Parkinson's, and ischemic stroke are serious conditions that currently lack effective treatments to slow their progression.
- Stilbenes, a group of natural compounds including resveratrol, have shown promise in protecting the nervous system by influencing cellular pathways involved in neurodegeneration.
- While preclinical studies suggest beneficial effects of stilbenes, especially resveratrol, clinical research is still limited and variable, highlighting the need for more targeted studies to fully understand their therapeutic potential.