Publications by authors named "N Vallet"
Energy metabolism of chimeric antigen receptor-T cells (CAR-T) activation in humans remains unexplored. As a glycolytic activity surrogate, we investigated the dynamics of peripheral blood (PB) lactate in the first weeks post-CAR-T infusion. In 17 patients treated with CD28 harbording anti-CD19 CAR-T for relapsed/refractory non-Hodgkin lymphomas, PB lactate levels increased following CAR-T infusion.
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- Donor cell engraftment is necessary for successful stem cell transplantation, but the cellular interactions in bone marrow during this process have not been well understood.
- Researchers used mass cytometry and CITEseq to analyze bone marrow cells three months after transplantation in patients with leukemia, finding significant changes in myeloid and B-cell progenitors, indicating a shift towards inflammation-driven hematopoiesis.
- The study concluded that bone marrow engraftment is marked by emergency hematopoiesis and an inflammatory response, particularly in patients who experienced graft-versus-host disease (GVHD).
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- Bispecific antibodies (BsAbs) are used to treat relapsed or refractory multiple myeloma, but frequent infections were noted during clinical trials, indicating a need for further real-world data on infection risks and outcomes.
- A multicenter retrospective study involving 229 patients in France from December 2020 to February 2023 found a high incidence of infections, with 234 recorded cases, primarily affecting the respiratory system, and a hospitalization rate of 56%.
- The study identified corticosteroids used for managing cytokine release syndrome as a risk factor for infections, while using GPRC5D-targeting BsAbs and antibacterial prophylaxis was associated with a reduced risk.
Vanilla production in Guadeloupe is expanding. The main species grown is , but other species such as are also present and required by industries. To upgrade the value of vanilla production on this Caribbean Island, this study was performed to evaluate the aromatic specifies of these vanilla species according to the length of the post-harvest period (2 months and 9 months).
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