Morphological Composition of Umbilical Cord Blood Cells and Their Functional Characteristics.

By the 23d week of fetus development cell content of umbilical cord blood becomes similar to that of fetus. This may be advantageous for determining cell content of fetus blood. In this connection our study was focused on morphological and functional characteristics of hemapoietic progenitors of umbilical cord blood.

[Cell composition of umbilical cord blood in complicated and uncomplicated pregnancy].

Possible influence of most frequently encountered types of pathology during pregnancy on the cell composition of umbilical cord blood was studied. These pathologies included: treated iron-deficiency anemia, essential hypertension, threatening spontaneous abortion. A number and proliferative potential of granulocyte-macrophage precursor cells of umbilical cord blood were studied by agar drop-liquid media culture method.

[Regulation of proliferation of stromal fibroblasts with methylprednisolone in cultures in vitro].

The effect of methylprednisolone [MP) in the concentration 10(-7) M on cloning capacity and proliferative potential of splenic and medullary stromal fibroblast precursors was studied in hematologically normal children. Medullary fibroblast culturing was performed according to A. Ya.

Granulocytopoiesis in children with acute lymphoblastic leukaemia.

Numbers, proliferative potential, and differentiative capacity of bone marrow granulocyte-macrophage precursor cells were studied in 130 children with acute lymphoblastic leukaemia (ALL), including 77 children in an acute phase of the disease and 53 in remission. Bone marrow samples from 65 children without haematopoietic abnormalities were used as controls. The numbers of clonogenic precursors were found to be below normal in all phases of ALL, particularly during the acute period when the bone marrow was heavily infiltrated with leukaemic cells.

[Granulocytopoiesis in acute lymphoblastic leukemia in children].

The number, proliferative potential and differentiation potentialities of bone marrow granulocytic-macrophagal precursors were investigated in 130 ALL patients (77 children in the acute period of disease, 53 children in remission) and in the bone marrow of 65 controls without hematologic pathology. A decrease in the number of clonogenic precursors was observed in all stages of acute lymphoblastic leukemia, the decrease being particularly marked in the acute period of disease characterized by substantial bone marrow infiltration by leukemic cells. A decrease in the number of precursors and their proliferative potential was shown to be associated with the influence of leukemic blasts.