Phase I/II trial of gene therapy with autologous tumor cells modified with tag7/PGRP-S gene in patients with disseminated solid tumors: miscellaneous tumors.

Background: The use of genetically modified autologous tumor cells appears to be a promising approach for cancer therapy. A phase I/II trial was undertaken to define the feasibility, safety and antitumor effects of the autologous vaccine prepared by transferring tag7/PGRP-S gene into malignant melanoma and renal cell carcinoma cells.

Patients And Methods: Twenty-one patients (17 with disseminated malignant melanoma and four with metastatic renal cell carcinoma) were enrolled in this study.

Cerebroprotective effects of diquertin and ascorbic acid.

Electron microscopy and electrophysiological studies revealed pronounced structural and functional changes in the brain cortex in rats with experimental cerebral ischemia. Repeated administration of diquertin and ascorbic acid significantly attenuates ischemic damage induced by circulatory disturbances.