[Markers of endothelial dysfunction: pathogenetic role and diagnostic significance.].

Endothelial dysfunction (ED) is considered one of the pathogenetic mechanisms of a whole range of diseases. Detection of specific biochemical markers in the blood is an effective way to ED diagnostics that characterize the vascular endothelium state. This review highlights the pathogenetic role of the factors synthesized by endotheliocytes whose level changes in biological fluids reflect violations of the endothelium basic physiological properties: vasomotor function, thromboresistance, angiogenesis regulation, barrier and adhesion functions.

ANALYSIS OF THE QUALITY OF NATIONAL VACCINE AGAINST RUBELLA.

Until recently Rubella has been a wide spread infection. Thanks to vaccination against rubella, taking part in the global elimination program of "manageable infections" of WHO and adoption of the program "Elimination of measles and rubella in Russian Federation" the morbidity index of rubella has reached the sporadic level. One of the determining conditions of rubella elimination is application of high-quality vaccines that satisfy international standards.

[Angiogenesis mechanisms in the formation of structural changes of brain tissue in patients with progressive cerebrovascular disease].

Aim: To study the correlation between expressiveness of focal changes of brain tissue and VEGF and MCP-1 levels in plasma and blood serum of patients with chronic cerebral ischemia (CCI).

Material And Methods: Markers of inflammation (MCP-1, CRP) and angiogenesis (VEGF) in serum and blood plasma of 35 patients with CCI depending on expressiveness of structural changes of brain substance according to MRI were investigated.

Results: The increase in MCP-1 and CRP content in blood serum and simultaneous decrease in VEGF level in serum and blood plasma were correlated with the increase in the number of focal changes of substance of the brain in patients with CCI.

[Markers of an inflammation and angiogenesis in chronic cerebrovascular diseases].

Aim: To study the diagnostic significance of additional vascular lesion markers in patients with chronic cerebral ischemia (CCI).

Material And Methods: Markers of inflammation (МСР-1, CRP) and angiogenesis (VEGF in blood serum and plasma) were studied in 50 patients with CCI and 60 healthy people.

Results And Conclusion: It was shown that the development of immunoinflammatory processes in patients with CCI is accompanied by the decrease in the content of vascular endothelial growth factor in the serum and blood plasma.

Exploring of primate models of tick-borne flaviviruses infection for evaluation of vaccines and drugs efficacy.

Tick-borne encephalitis virus (TBEV) is one of the most prevalent and medically important tick-borne arboviruses in Eurasia. There are overlapping foci of two flaviviruses: TBEV and Omsk hemorrhagic fever virus (OHFV) in Russia. Inactivated vaccines exist only against TBE.