[STATE OF NONALLERGIC HYPERSENSITIVITY UNDER THE EXPOSURE TO ADVERSE ENVIRONMENTAL FACTORS].

Now a number of allergopatologies is shown to be formed as non-allergic hypersensitivity. Research of this state is especially important when studying a question of formation of a condition of a chemical sensitization in response to the contact of a human body with chemical pollutants. For diagnostics of reactions of non-allergic hypersensitivity the test was developed for an assessment of activation of basophiles by specific allergens (the test of activation of basophiles by method of a flowing cytometry Flow Cast® (BD FACSCalibur)).

[Experimental data for evaluation of biological effect during exposure to chemical and biological factors].

Joint effects of lysin, eprin and formaldehyde in acute and subacute experiments were investigated. As shown, this effect can be evaluated as a partial summing with coefficient 1.84.