MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Electrospinning of methacrylated alginate for tissue engineering applications.

Photo-crosslinkable methacrylated alginate derivatives (M-ALGs) were synthesized modification of sodium alginate with glycidyl methacrylate. Needle (capillary) and needleless electrospinning techniques were employed to produce their nonwoven fiber mats. Spinning parameters such as applied voltage, solution composition, and flow rate were optimized to form uniform bead-free fibers with an average diameter of about 150 nm.

[Predictors of New-Onset Atrial Fibrillation in Patients With Chronic Coronary Artery Disease After Coronary Artery Bypass Grafting: a Prospective, Observational, Single-Centre, Non-Randomized Study].

Aim: To study the factors that influence the occurrence of postoperative atrial fibrillation (POAF) in patients with chronic ischemic heart disease (IHD) after coronary artery bypass grafting (CABG).

Material And Methods: This single-center prospective observational non-randomized study included 152 patients with chronic IHD. Mean age of patients was 64.

Assessment and Validation of Small-Scale Tropospheric Delay Estimations Based on NWP Data.

This paper investigates the applicability of the Numerical Weather Prediction (NWP) data for characterizing the gradient of zenith wet delay in horizontal direction observed on short baselines over larger territories. A three-year period of data for an area covering Scandinavia and Finland is analyzed, and maximum gradients during the considered period are identified. To assess the quality of the NWP-based estimates, results for a smaller region are compared with the estimates obtained using Global Navigation Satellite System (GNSS) measurements processed by the GipsyX/RTGx software package (version 2.