[Sevoflurane optimal dosage estimation for myocardium pharmacological postconditioning: an experimental study].

We estimated the optimal dosage of inhalation anesthetic sevoflurane, for the maximum cardioprotective effect with minimal angioparalytic action. 25 pigs were included in this study, they were divided into 5 groups, depending on the sevoflurane dosage used for pharmacological postconditioning (PPC): control group - PPC has't been conducted, a group of PPC 0.5 - sevoflurane PPC in a dose of 0.

[Effect of perfusion volume of the Custodiol solution on the efficiency of cardioplegia in experiment].

The purpose of the present study was to compare the efficiency of small and standard volumes (1.5-20 and 7-10 ml/g of the myocardium, respectively) of Custodiol solution in myocardial ischemia lasting 2 and 4 hours. Experiments were carried out on 24 mongrel dogs weighing 22-36 kg under extracorporeal circulation (EC) with bicaval cannulation under moderate general hypothermia and balanced general intravenous anesthesia.