Publications by authors named "N V Singh"
White matter hyperintensities (WMH) of presumed vascular origin are a magnetic resonance imaging (MRI)-based biomarker of cerebral small vessel disease (CSVD). WMH are associated with cognitive decline and increased risk of stroke and dementia, and are commonly observed in aging, vascular cognitive impairment, and neurodegenerative diseases. The reliable and rapid measurement of WMH in large-scale multisite clinical studies with heterogeneous patient populations remains challenging, where the diversity of imaging characteristics across studies adds additional complexity to this task.
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- Bacterial blight in pomegranate, caused by Xanthomonas citri pv. punicae (Xcp), is a major issue leading to significant economic losses, with current management primarily relying on antibiotics and copper-based treatments.
- The excessive use of antibiotics has led to antibiotic resistance, prompting research into eco-friendly alternatives like native endophytes, which are beneficial bacteria isolated from pomegranate plants that can inhibit Xcp growth through the production of antimicrobial volatiles.
- Field trials showed that using these endophytes reduced the disease index by 47-68%, outperforming traditional chemical treatments, making them promising candidates for sustainable bacterial blight management in pomegranate cultivation.
Study Design: Retrospective cohort study.
Objective: to analyze trends in PROMs improvement and recovery kinetics following transforaminal endoscopic lumbar discectomy and foraminotomy (TELD).
Summary Of Background Data: As TELDs become an increasingly common alternative to fusions for lateral disc herniations, it is important to understand patients' postoperative recovery timelines to manage patient expectations.
The research focuses on the characterization and evaluation of drug delivery efficiency of a microwave-assisted, free-radical synthesized polyacrylamide-grafted Assam Bora rice starch (ABRS) graft copolymer (ABRS-g-PAM). Percentage grafting efficiency (% GE) and intrinsic viscosity were chosen as the optimization parameters. The optimized ABRS-g-PAM Grade Formulation 4 (GF4) was found to be the best grade.
View Article and Find Full Text PDFBackground: Elinzanetant is a dual neurokinin-1,3 receptor antagonist in development for the treatment of menopausal vasomotor symptoms. The objectives of these studies were to characterize the mass balance and biotransformation of elinzanetant.
Methods: In the clinical evaluation, whole blood, plasma, urine, and feces were collected from healthy fasted male volunteers (n = 6) following a single dose of 120 mg [C]-elinzanetant oral suspension for analysis of total radioactivity and metabolite profiling.