Non-associative potentiation of proximal excitatory inputs to layer 2/3 pyramidal cells in rat visual cortex.

Long-term changes of synaptic transmission can be induced by Hebbian-type homosynaptic mechanisms which require activation of both pre- and postsynapse and mediate associative learning, as well as by heterosynaptic mechanisms which do not require activation of the presynapse and are non-associative. The rules for induction of homosynaptic plasticity depend on the distance of the synapse from the soma. Does induction of heterosynaptic plasticity also depend on synaptic location? Here, we investigated heterosynaptic changes in pharmacologically isolated glutamatergic inputs arriving at either the proximal or the distal segments of the apical dendrite of layer 2/3 pyramidal neurons in rat visual cortex.

The Functional States of the Participants of a Marine Arctic Expedition with Different Levels of Vitamin D in Blood.

(1) Background: The vitamin D level in blood is one of the markers of the functional reserves of the human body and can contribute to more successful adaptation in the Arctic. (2) Methods: The study involved 38 participants in the project "Arctic Floating University-2021". The determination of vitamin D content was carried out at the beginning of the expedition.

The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats.

Sea buckthorn (Hippophae rhamnoides L.) is described by various beneficial effects as it contains several bioactive substances characterized by antioxidant effects. These effects are closely related to the reduction of oxidative stress that is involved in the development of the disease.

Enhanced Non-Associative Long-Term Potentiation in Immature Granule Cells in the Dentate Gyrus of Adult Rats.

The dentate gyrus is one of the few sites of neurogenesis in the adult brain. Integration of new-generated granule cells into the hippocampal circuitry provides a substrate for structural plasticity, fundamental for normal function of adult hippocampus. However, mechanisms of synaptic plasticity that mediate integration of new-generated granule cells into the existing circuitry remain poorly understood.

[Experience of using Reamberin for the correction of cognitive impairment and antioxidant status in the late period of traumatic brain injury].

Objective: To study the efficacy of Reamberin in cognitive impairment in patients associated with traumatic brain injury, taking into account its effect on the parameters of neuropsychological and antioxidant status.

Material And Methods: We examined 45 patients aged 35 to 60 years with cognitive impairment in the late period of traumatic brain injury. The patients were divided into two groups depending on the prescribed treatment.