Parameters of high-density lipoproteins in patients with arterial hypertension in combination with other components of metabolic syndrome.

Parameters of HDL (concentrations of cholesterol, apoprotein A1, and phospholipids and phospholipid composition) determining their functional properties were studied in patients with arterial hypertension in combination with other components of metabolic syndrome (abdominal obesity, hyperlipidemia, and impaired glucose tolerance). Patients with isolated arterial hypertension did not differ from the control group by the concentration of apoprotein A1 and HDL cholesterol, but had lower content of HDL phospholipids and changed phospholipid composition: lower ratio of phosphatidylcholine and higher relative contents of lysophosphatidylcholine, sphingomyelin, and phosphatidylethanolamine. Parameters of HDL in patients with arterial hypertension associated with other components of metabolic syndrome did not differ from those in patients with isolated arterial hypertension.

[Signs of metabolic syndrome in combinations of hypertension with coronary risk factors].

Anthropometric data, parameters of lipoprotein spectrum and carbohydrate metabolism were obtained from 115 men aged 34-67 years with hypertension. Hypertension combined with any other criterion of metabolic syndrome was associated with deviations of parameters of insulin resistance, blood pressure, body mass index, waist circumference, levels of cholesterol, low density lipoproteins and lipoprotein (a) similar to those observed in complete metabolic syndrome. Combinations of hypertension with hypercholesterolemia and/or excessive body mass were not associated with signs of insulin resistance in the presence of higher then in isolated hypertension values of body mass index, cholesterol, low density lipoprotein cholesterol.

Low-density lipoprotein subfractions during abdominal and gluteofemoral obesity.

Subfractional spectrum of plasma low-density lipoproteins in people with normal body weight and patient with obesity was studied by gradient electrophoresis (3-12%) in polyacrylamide gel. Low-density lipoprotein subfractions in fasting patients with abdominal and gluteofemoral obesity were primarily presented by small particles (compared to people with normal body weight). The composition of low-density lipoprotein subfractions underwent most pronounced changes in patients with abdominal obesity after single fat load.

[Effect of nutrition factors on the subfractional spectrum of high density lipoproteins].

High amount of animal lipids containing in a diet of 5 persons examined led to increase in content of lipids and of subfraction 3b of high density lipoproteins (HDL) as well as to decrease of the HDL 3a subfraction in their blood plasma. Hypocholesterolemic diet, used for medical purposes in 5 patients with heart ischemic disease within 4 weeks, caused the opposite alterations in the HDL subfraction spectrum of all the patients studied: a decrease in 3b subfraction and an increase in 3a subfraction content. Any alterations in the patterns studied, estimated every week, were not observed in the control group (5 persons) maintained on usual diet without certain dietetic or medical recommendations.