Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration.

Aquaporin 3 (AQP3) channels are tetrameric membrane-bound channels that facilitate the transport of water and other small solutes across cell membranes in the skin. Decreased AQP3 expression is associated with skin dryness, skin aging, psoriasis, and delayed wound healing. Thus, our study focused on a novel combination based on leaf extract and trimethylglycine for targeted AQP3 regulation in skin keratinocytes and deep skin moisturization.

[Two models of insulin resistance development and the strategy to combat age-related diseases: literature review].

Background: Insulin resistance (IR) is the root cause of most age-related diseases (ARD), the major challenge for today's health systems. Therefore, adequate understanding of the mechanisms underlying IR is essential to build effective ARD prevention.

Objective: Analyze the existing models of IR causation and progression in order to justify the most effective ARD prevention strategy.

[Hyperinsulinemia and age-related diseases: interrelations and approaches to treatment].

Hyperinsulinemia is closely related with insulin resistance, that is the key mechanism for the progression of age-related diseases. A lot of aspects of hyperinsulinemia and interrelations between the mentioned conditions are very scarcely covered in Russian publications. The present review is designed to fill the gaps in understanding the causal relationships between hyperinsulinemia, insulin resistance, age-related diseases and lifestyle factors.

Navigated transcranial magnetic stimulation in amyotrophic lateral sclerosis.

Introduction: Amyotrophic lateral sclerosis (ALS) is a set of disorders associated with preferential degeneration of both upper and lower motor neurons. Navigated transcranial magnetic stimulation (nTMS) is a tool used to perform noninvasive functional brain mapping. We aimed to assess function of upper motor neurons in ALS.

Granular superconductors and a sandpile model with intrinsic spatial randomness.

We present a model for investigation of self-organized criticality applicable to a real physical system: a granular superconductor. The model demonstrates self-organized behavior even in circumstances when other models do not.