Complexity measure in natural time analysis identifying the accumulation of stresses before major earthquakes.

Here, we suggest a procedure through which one can identify when the accumulation of stresses before major earthquakes (EQs) (of magnitude M 8.2 or larger) occurs. Analyzing the seismicity in natural time, which is a new concept of time, we study the evolution of the fluctuations of the entropy change of seismicity under time reversal for various scales of different length i (number of events).

Phase I Study of a Multivalent WT1 Peptide Vaccine (Galinpepimut-S) in Combination with Nivolumab in Patients with WT1-Expressing Ovarian Cancer in Second or Third Remission.

We examined the safety and immunogenicity of sequential administration of a tetravalent, non-HLA (human leukocyte antigen) restricted, heteroclitic Wilms' Tumor 1 (WT1) peptide vaccine (galinpepimut-S) with anti-PD-1 (programmed cell death protein 1) nivolumab. This open-label, non-randomized phase I study enrolled patients with WT1-expressing ovarian cancer in second or third remission from June 2016 to July 2017. Therapy included six (every two weeks) subcutaneous inoculations of galinpepimut-S vaccine adjuvanted with Montanide, low-dose subcutaneous sargramostim at the injection site, with intravenous nivolumab over 12 weeks, and up to six additional doses until disease progression or toxicity.

Earthquake Nowcasting: Retrospective Testing in Greece.

Earthquake nowcasting (EN) is a modern method of estimating seismic risk by evaluating the progress of the earthquake (EQ) cycle in fault systems. EN evaluation is based on a new concept of time, termed 'natural time'. EN employs natural time, and uniquely estimates seismic risk by means of the earthquake potential score (EPS), which has been found to have useful applications both regionally and globally.

Estimating the Epicenter of a Future Strong Earthquake in Southern California, Mexico, and Central America by Means of Natural Time Analysis and Earthquake Nowcasting.

It has recently been shown in the Eastern Mediterranean that by combining natural time analysis of seismicity with earthquake networks based on similar activity patterns and earthquake nowcasting, an estimate of the epicenter location of a future strong earthquake can be obtained. This is based on the construction of average earthquake potential score maps. Here, we propose a method of obtaining such estimates for a highly seismically active area that includes Southern California, Mexico and part of Central America, i.

Shooting solitaries due to small-world connectivity in leaky integrate-and-fire networks.

We study the synchronization properties in a network of leaky integrate-and-fire oscillators with nonlocal connectivity under probabilistic small-world rewiring. We demonstrate that the random links lead to the emergence of chimera-like states where the coherent regions are interrupted by scattered, short-lived solitaries; these are termed "shooting solitaries." Moreover, we provide evidence that random links enhance the appearance of chimera-like states for values of the parameter space that otherwise support synchronization.