[Proliferative response and suppressor activity of lymphocytes in candidiasis].

In 14 practically healthy donors, 22 patients with chronic candidiasis of the skin and mucosa (CCSM) and 14 patients with chronic candidal vulvovaginitis (CCW) immunoregulating factors synthesized by peripheral blood lymphocytes under the conditions of in vitro induction of suppressor cells were studied in comparison with the proliferative response to PHA and Candida albicans cytoplasmic protein. In practically healthy donors the level of lymphocyte response to mitogen coincided with the presence of the inhibiting activity of supernatants. In a more severe form of Candida infection (CCSM) the proliferative reaction of lymphocytes to both PHA and C.

[The phagocytic activity of the neutrophilic granulocytes in patients with chronic candidiasis of the skin and mucous membranes].

24 patients with chronic candidiasis of the skin and mucous membranes have been examined. The following parameters have been evaluated: (1) ingestive capacity, (2) fungicidal capacity, (3) the state of the myeloperoxidase mechanism of respiratory explosion. In chronic candidiasis of the skin and mucous membranes the ingestive capacity of neutrophil granulocytes has been found to remain unchanged, constituting 70 +/- 3.

[Modifications to the surface of T-lymphocytes in chronic candidiasis of the skin and mucous membranes].

27 patients with chronic candidiasis of the skin and mucous membranes have been examined with a view to study the expression of E-receptors and its changes after the incubation of T-lymphocytes with theophylline, levamisole, thymaline and Candida albicans antigen. This study has revealed that, in comparison with healthy persons, most patients show decreased expression of E-receptors, and the character of their changes after incubation with the above-mentioned preparations is essentially different. The deviations revealed in this study have been regarded as the modification of T-cell membranes, which is seemingly one of the reasons of the weak competence of T-cells.

[Diagnosis of allergic bronchopulmonary aspergillosis].

Five patients (4 men and 1 woman) afflicted with bronchopulmonary aspergillosis (ABPA) were examined. The main criteria for the diagnosis were a high level of the total IgE, demonstration of specific IgE to Aspergillus fumigatus, positive skin tests with antigens of moldy fungi. All the 4 patients with active process, not given corticosteroids, manifested eosinophilia of the sputum and peripheral blood.