Pharmacokinetic properties of the antimuscarinic drug [3H]-hexahydro-sila-difenidol in the rat.

The pharmacokinetics of tritiated hexahydro-sila-difenidol [( 3H]-HHSiD) were examined in rats. Furthermore, the distribution of radioactivity was studied by means of whole body autoradiography. After i.

Histological analysis of ultrasonic images of the prostate: an accurate technique.

Ultrasonography of the prostate furnishes images which still cannot be fully interpreted morphologically. In a cadaver study, the ultrasound images of two groups (21 and 19) prostates, obtained in a water bath, were compared with histology slides taken at corresponding levels. In the first part of the study, using a 4 MHz probe, there was a correlation between hyperechoic lesions and stone formations in 9 out of 15 cases.

Whole body distribution of the quaternary ammonium compound thiazinamium (N-methylpromethazine) and promethazine in monkey and mice.

The distribution of 35S-ringlabeled thiazinamium (N-methyl-promethazine) methylsulphate (35S-Th.) and its tertiary analog 35S-promethazine hydrochloride (35S-Pr.) have been studied by means of whole body autoradiography in a squirrel monkey and in mice.

Whole-body autoradiography after systemic and topical administration of methyl acrylate in the guinea pig.

Whole-body autoradiography was performed in the guinea pig with methyl (2,3-14C)-acrylate. Radioactive material quickly disappeared from the body after oral and, somewhat slower, after i.p.