Publications by authors named "N V Ravi"
A metal- and solvent-free, one-pot and TFA-promoted method for the construction of hetero/aryl-substituted quinoxalin-2-ones, pyrazin-2(1)-ones, and pyrimidin-4(3)-ones is reported. This method involves the reaction of chloro-derivatives of nitrogen heterocycles with electron-rich arenes/heteroarenes, followed by hydroxylation. This protocol is easy to use, providing access to (hetero)aryl-substituted -heterocycles in good yields.
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- Recent studies indicate that base editing can cause significant deletions in specific gene regions, which may reduce its therapeutic effectiveness even when fewer deletions occur compared to traditional Cas9 methods.
- The research explores using a dCas9 fusion of ABE8e instead of nickaseCas9 to maintain editing efficiency while minimizing these deletions in human hematopoietic stem and progenitor cells (HSPCs).
- Findings reveal that dABE8e allows for effective editing without creating large deletions, leading to a safer method for genome editing with improved precision.
In parallel with improved operative and oncologic outcomes for esophageal cancer, paraconduit hiatus hernia (PHH) is an increasingly recognized entity, both in the early postoperative phase and in long-term follow-up. The aim of this study was to assess the incidence of and risk factors for PHH, and to describe management approaches in a tertiary referral center. All patients undergoing surgery with curative intent for esophageal cancer from 2008 to 2022 at a single center were included.
View Article and Find Full Text PDFInhibition of AP-2-associated protein kinase 1 (AAK1) has been shown to be a promising avenue for the development of broad-spectrum antiviral agents. On a previously described AAK1 inhibitor based on a pyrrolo[2,3-b]pyridine scaffold, the concept of isosterism was applied, by replacing a carboxamide linker by various five-membered heterocycles. It led to the discovery of a novel series of AAK1 inhibitors with IC values in the low nM range, that also displayed antiviral activity against the dengue virus and Venezuelan equine encephalitis virus.
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- Neuroblastoma (NB) is a highly aggressive childhood cancer that often becomes resistant to treatment, making it particularly deadly.
- Researchers studied tumor regions from 12 NB patients and found that, after chemotherapy, the initial densely packed subclones were replaced by diverse "survivor" subclones that had different ancestors.
- The study revealed that tumors progressing during treatment already contained ancestor subclones, indicating a pattern where numerous distinct subclones appear early on and contribute to clonal evolution during chemotherapy.