[Remote effects of Aroclor 1254 on the rat liver microsomal monooxygenase activity in acute pancreatitis].

Constitutive activities of the liver cytochromes P450 1A1, 1A2, 2C6 and 2B1 were lower in rats with the acute experimental pancreatitis during ten days of this disease. In rats pretreated with a single dose of Arochlor 1254 on the second day of pancreatitis activities of these enzymes remained elevated to the tenth day. Thus, acute pancreatitis caused long-term suppression of microsomal monooxygenase system, whereas induction by Arochlor 1254 increased cytochromes P450 activity in both control animals and in rats with pancreatitis.

[Changes in the microsomal monooxygenase system of the rat liver in acute pancreatitis and during induction by Aroclor 1254].

The effect of Arochlor 1254 treatment of rats on activities of cytochrome P450 isoforms 1A1, 1A2, 2C6 was investigated under conditions of acute pancreatitis. Irrespectively to the scheme of Arochlor 1254 administration (before the development of pancreatitis, and at various periods after its provocation) cytochrome P450 activities were higher than in corresponding controls.

Glutathione S-transferase activity in the liver in acute pancreatitis at various terms of disease and during treatment with inducers.

Glutathione S-transferase activity increased in rats with acute pancreatitis: 2.2 times on day 2, 2-fold on day 4, and 1.5 times on day 10.

Time course of malonic dialdehyde and alpha-tocopherol in rat pancreas during the first hours of acute pancreatitis.

Time course of malonic dialdehyde and alpha-tocopherol levels in rat pancreas during the first day of experimental pancreatitis indicates activation of lipid peroxidation and components of the antioxidant system in the involved organ.

[Change in the rat liver microsomal monooxygenase system upon induction with phenobarbital in acute pancreatitis].

While injecting phenobarbital (PB) into the rats, on the second day of an experimental pancreatitis, cytochrome P450 2B1 and 2C6 activities were found, on the forth day of disease, as being considerably higher in comparison with data obtained in sham-operated control animals. On the tenth day of the acute pancreatitis (in three days upon having the induction canceled), activity of the cytochrome P450 isozymes was lower than that of control animals. Thus, the rats with acute pancreatitis, are characterized by an increased indycibility of liver monooxygenases.