Correlation between circulating corticosterone and protein carbonylation in the liver after short-term hypokinesia.

We studied the correlation of the concentration of circulating corticosterone and parameters of dexamethasone suppression test with the level of protein carbonylation in the liver after short-term hypokinesia. Increasing hypokinesia duration was followed by worsening of disturbances in the hypothalamic-pituitary-adrenal system via a negative feedback mechanism and enhanced protein carbonylation in the liver.

Effects of preliminary hypokinetic stress on sensitivity of the bone marrow to the hypoplastic effect of exogenous glucocorticoid.

We studied the cell composition and free radical oxidation in the bone marrow of white outbred rats after hypokinetic stress (24 and 72 h) and the effects of exogenous glucocorticoid triamcinolone acetonide (2 mg/kg; injected 24 h after hypokinesia); the measurements were performed in 96 h after drug administration. The hypoplastic effect of the glucocorticoid after 24-h hypokinesia was observed against the background of reduced free radical oxidation. In animals subjected to 3-day hypokinesia, the resistance of the bone marrow to the hypoplastic effect of this drug was accompanied by activation of free radical processes.

[Peculiarities of adaptive hemodynamic processes during high-frequency jet lung ventilation].

This study concerns poorly known features of adaptive hemodynamic reactions of the heart pump function during traditional and high-frequency jet lung ventilation. Spectral analysis of slow-wave oscillations of stroke volume and left ventricular diastolic filling wave in 36 patients with craniocerebral injury and acute cerebral insufficiency showed that beneficial adaptive reactions were realized through a rise in the general spectrum power and entropy. High-frequency jet lung ventilation ensured better effect on the adaptive processes than the traditional technique.