Spatial recognition in cats: effects of parahippocampal lesions.

The role of the posterior parahippocampal area of the brain in spatial types of memory in conditions of one-trial visual perception of the positions of objects was studied by training eight cats to remember the spatial positions of either two different objects covering two of three feeders placed on a test tray (tests for the "object-place" association) or the positions of two of three feeders (tests for place). Each trial used new objects and new positions for the two of three feeders. After training, four cats were subjected to electrolytic lesioning of the posterior parahippocampal area, primarily the parahippocampal cortex, parasubiculum, and presubiculum; the remaining four cats underwent all the surgical procedures except electrocoagulation of nervous tissue; this was the sham-operated control group.

[Spatial recognition in cats: effects of parahippocampal lesions].

To determine the contribution of the posterior parahippocampal region to spatial form of one-trial memory in cats, we trained 8 cats to remember the spatial positions of either two different trial-unique objects overlying two of three feeders in a feeder test tray (object-place trials) or simply two of the three feeders (place trials). Four cats then received electrolytic lesions restricted to the posterior parahippocampal region (experimental group) including mainly parahippocampal cortex, parasubiculum and presubiculum. Four other cats comprised sham-operated control group.

[The optimization of the treatment of epilepsy with carbamazepine in puberty].

A study was made of the pharmacokinetics of carbamazepine (CBZ) in epileptic patients in the pubertal period. In a group of patients with fully controlled fits, the concentrations of CBZ ranged within the mean values of the therapeutic concentration. Meanwhile in a group with an incomplete therapeutic effect and without any effect, the mean dose of CBZ per kg weight was even higher than that in the group with fully controlled fits.