Publications by authors named "N V Okhrimenko"

A relationship between childhood starvation and type 2 diabetes mellitus (T2D) in adulthood was previously indicated. Ukraine suffered a series of artificial between 1921 and 1947. Famines of 1932 to 1933 and 1946 were most severe among them.

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Type 2 diabetes mellitus is characterized by shorter leukocyte telomere length, but the relationship between leukocyte telomere length and type 2 diabetes mellitus development is rather questioned. Fasting and post-load glycaemia associated with different types of insulin resistance and their relation with leukocyte telomere length remains unknown. We compared leukocyte telomere length and fasting or post-load glucose levels in persons who do not receive glucose lowering treatment.

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Background: Whereas an increase of neck circumference (NC) had been recently identified as a new independent cardiovascular disease (CVD) and metabolic syndrome risk factor, similar assessments concerning screen-detected diabetes mellitus (SDDM) have not been made. Thyroid gland volume (ThV) can potentially affect NC however the significance of this influence concerning the risk of NC-related disease is unknown.

Methods: We performed a ThV-adjusted evaluation of NC within a population-based investigation of SDDM and impaired glucose regulation (IGR) prevalence.

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The aim of present observational cross-sectional study was the estimation of the gender-related risk of non-fatal stroke, myocardial infarction and blindness in type 2 diabetics (T2D) depending on treatment in Ukraine. In Dec 2005 the data from 11 Ukrainian regions for all living T2D already included into the nationwide population-based diabetes register (start of creation Jan 2001) was extracted. Male/female relative risks (RRs) for non-fatal stroke, myocardial infarction and blindness were calculated in treatment groups: Diet only (DO) 7273/15901; oral antidiabetic drugs (OAD) 15109/ 33913; insulin (I) 5529/12462 male/female respectively.

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Article Synopsis
  • The study examined the effects of induced acute myocardial ischemia in alloxane-diabetic dogs under anesthesia, focusing on cardiovascular reactions.
  • The systemic circulation responses during ischemia were similar in diabetic dogs with moderate and mild hyperglycemia compared to healthy controls, but their coronary artery dilation and recovery were less efficient.
  • In dogs with severe diabetes (high hyperglycemia), typical responses to ischemia were diminished or absent, leading to a significantly slower recovery of heart function and metabolic processes during reperfusion.
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