The Social Return on Investment in programs designed for young people living with a family member who experiences mental health challenges: study protocol.

The purpose of this paper is to describe the protocol for the evaluation of programs offered by the Satellite Foundation, designed for, and with, children and young people aged between 8 and 25 years who have family members experiencing mental health challenges. To achieve this, the Social Return on Investment (SROI) method was chosen. SROI is an economic measurement tool used to apply a monetary value to socially situated outcomes.

PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling.

RNF168 orchestrates a ubiquitin-dependent DNA damage response to regulate the recruitment of repair factors, such as 53BP1 to DNA double-strand breaks (DSBs). In addition to its canonical functions in DSB signaling, RNF168 may facilitate DNA replication fork progression. However, the precise role of RNF168 in DNA replication remains unclear.

Smart Design for Hybrid Bioprinting of Scalable and Viable Tissue Constructs.

Hybrid bioprinting uses sequential printing of melt-extruded biodegradable thermoplastic polymer and cell-encapsulated bioink in a predesigned manner using high- and low-temperature print heads for the fabrication of robust three-dimensional (3D) biological constructs. However, the high-temperature print head and melt-extruded polymer cause irreversible thermal damage to the bioprinted cells, and it affects viability and functionality of 3D bioprinted biological constructs. Thus, there is an urgent need to develop innovative approaches to protect the bioprinted cells, coming into contact or at close proximities to the melt-extruded thermoplastic polymer and the high-temperature print head during hybrid bioprinting.

Development and characterisation of suitably bioengineered microfibrillar matrix-based 3D prostate cancer model fordrug testing.

Bioengineered 3D models that can mimic patient-specific pathologiesare valuable tools for developing and validating anticancer therapeutics. In this study, microfibrillar matrices with unique structural and functional properties were fabricated as 3D spherical and disc-shaped scaffolds with highly interconnected pores and the potential of the newly developed scaffolds for developing prostate cancer model has been investigated. The newly developed scaffolds showed improved cell retention upon seeding with cancer cells compared to conventional electrospun scaffolds.