Publications by authors named "N V Musatova"

Chemotherapy for disseminated tuberculosis by the schemes regulated by the Order "On Improvement of Tuberculosis-Controlling Measures in the Russian Federation" issued by the Ministry of Health of the Russian Federation under No. 109 on March 21, 2003, leads to the regression of intoxication syndrome and the normalization of general blood analysis parameters in most patients, provides bacterial excretion cessation in 72.7% of the patients and decay cavity closure in 53.

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The course of generalized tuberculosis in a northern region is mainly characterized by its subacute onset; moreover, the symptoms of intoxication and the bronchopulmonary manifestations of the disease are observed practically in all patients. Socially dysadapted individuals are most susceptible to this disease. Even if patients with generalized tuberculosis have significant symptoms of the diseases, only a few of them resort to a health care facility within a month after their occurrence.

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The hormonal regulation of lipid peroxidation (LPO) and the status of the body antioxidant system has been studied insufficiently. The purpose of the present study was to investigate the effect of insulin on the activity of antioxidant enzymes (superoxide dismutase--SOD and catalase--CT) and at the same time on the level of LPO products in erythrocytes. Cells were incubated with insulin at different concentrations in own plasma for 2 h at 37 degrees C.

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Alterations in superoxide dismutase activity, observed in erythrocytes of children with insulin-dependent form of diabetes mellitus, depended on the age of patients, severity and degree of the disease compensation. Content of lipid peroxidation products was also dissimilar in compensated and decompensated forms of diabetes mellitus. Activity of catalase in erythrocytes of patients was similar to corresponding values of healthy children and did not depend on the disease stage and severity.

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