On normalizing of urinary KIM-1 level to urine creatinine in patients with renal cell cancer.

KIM-1 (kidney injury molecule 1), a marker of acute kidney injury, is produced by epithelial cells of renal proximal tubules. Elevated KIM-1 levels in urine and plasma are associated with renal cell carcinoma (RCC). The aim of this study was to compare the significance of non-normalized uKIM-1 values and those normalized to urine creatinine, as urinary biomarkers in RCC.

Study of growth parameters and potentialities of differentiation of multipotent mesenchymal stromal cells from rat bone marrow in vitro.

The dynamics of growth and proliferative activity of the population of multipotent mesenchymal stromal cells from rat bone marrow was studied during 7 passages. The efficiency of colony formation, the morphology of multipotent mesenchymal stromal cells, and the possibility of spontaneous and induced differentiation were studied. The rat bone marrow fibroblast-like multipotent mesenchymal stromal cells are capable of clonal growth; their proliferative activity and the yield remained high until passage 4, but then decreased.

[Tumor-associated antigen CA-125 in patients with ovarian cancer receiving various combinations of therapy].

A dynamic immuno-enzymatic assay of CA 125 was carried out in 43 patients (230 tests) with ovarian tumors receiving chemotherapy alone (group 1), surgery + adjuvant chemotherapy (group 2), or neoadjuvant chemotherapy + surgery + adjuvant chemotherapy (group 3). Mean concentration of CA 125 before treatment was 1,635.0 (362.