Prognostic significance of microRNA-200b and ERCC1 expression in tumor cells of patients with esophageal cancer.

Background: The development of malignant tumors, including esophageal cancer (EC), could be associated with impaired expression of oncosuppressive miRNA-200b and еxcision repair cross-complementing group-1 (ERCC1), a protein involved in DNA repair and alternative splicing.

Aim: To investigate the features of expression of miRNA-200b and ERCC1 in tumor cells of patients with EC and to determine the possibility of their use for prediction of EC aggressiveness.

Materials And Methods: 52 patients with EC of stages II-IV were enrolled.