[The prognostic significance of pre-existing lymphocytotoxic antibodies in cadaveric kidney allografts with a negative specific crossmatch].

The paper presents the results obtained on preexisting lymphocytotoxic antibodies in 110 patients with the use of cryopreserved donor lymphocytes. Preexisting antibodies (PA) are shown to display in 52% of primary patients in the nephrological department. Follow-up measurements gave evidence on PA levels fluctuations following an undulating form.

[The use of monoclonal antibodies for determining the transferrin content of the urine].

The authors used monoclonal antibodies to human transferrin for the development of a high-sensitive test system for the assessment of transferrin levels in urine with enzyme immunoassay. The conditions of the immunoassay performance were optimized. The sensitivity of the test system enabled the authors to define the levels of transferrin up to 1 ng/ml.

[The characteristics of proteinuria during intensive physical loading].

Intensive physical exercise result in certain changes in the body, kidneys in particular. A total of 23 highly qualified sportsmen were investigated for plasma proteins in the urine before and after the graded bicycle ergometry. The impairment of renal reabsorption due to physical load was evidenced by significant amounts of albumin in the afterload urinalyses of all the examinees, and the appearance of IgG in urinalysis of 6 sportsmen in comparison to the urinalysis before the exercise which reported insignificant levels of albumin in 6 subjects only.

[Reprocessing of capillary dialyzers].

Changes in biocompatibility parameters of the cuprophan membrane, used repeatedly after reprocessing, were assessed. It is demonstrated that when the dialyzer is applied for the second of third time, cuprophan membrane loses its ability to induce acute dialysis leucopenia, typical for first application. Repeatedly used dialyzers also failed to cause bone-marrow irritation, which at first use induced a release of juvenile neutrophils into the circulation.

[The content of the carcinoembryonic antigen in the blood serum of patients with bladder tumors at various stages of combined treatment in relation to the disease stage].

Serum level of a tumor marker, carcinoembryonic antigen (CEA), was examined in patients at different stages of vesical cancer before and during combined treatment, including preoperative large-fraction radiotherapy and surgery. Sixty patients with histologically documented vesical cancer, stages T1N0M0, T2N0M0, T3N0-1M0 and T4N0M0 were investigated. All patients underwent large-fraction radiotherapy prior to surgery.